On December 3, 2025, 14 countries in Europe reported 1,112 locally acquired cases of WNV infection in humans. The earliest and latest onset dates were May 19, 2025, and October 27, 2025, respectively. Locally acquired cases have been reported by Italy (779), Greece (96, including 1 with an unknown place of infection), France (62), Serbia (62), Romania (49), Spain (36), Hungary (14), Croatia (4), Albania (3), Germany (2), North Macedonia (2), Bulgaria (1), Kosovo* (1), and Turkey (1). In Europe, 97 deaths were reported.

The number of reported cases this year was above the average of the past decade (758). However, these figures remained lower than those of 2018, 2022, and 2024, years in which the virus circulated particularly intensely and more than 1,300 cases were reported.

This year, Italy experienced a major outbreak, with 779 confirmed human cases, including 72 deaths (a mortality rate of 9.2%, which is within the expected range). This is the highest number of human WNV cases reported by Italy in a single year. Most cases (267) were reported in the Lazio region (Latina, Rome, and Frosinone), followed by 133 cases in the Campania region (Naples, Caserta, Salerno, and Avellino). Other regions reported numbers similar to previous years. Furthermore, France reported more cases than in any other year, and 14 regions reported cases for the first time.

As of December 3, 2025, locally acquired human WNV infection cases had been reported in 157 regions across 14 countries.